Flights from Madrid Airport to Santiago Metropolitan Region

Flight deals from Madrid Airport to Santiago Metropolitan Region

Looking for cheap tickets from Madrid Airport to Santiago Metropolitan Region, or a last-minute trip? Find the lowest prices on one-way and return tickets right here.

Flying from Madrid Airport to Santiago Metropolitan Region

Arm yourself with these facts on the fly.
Cheapest flight found649 €, Santiago
Cheapest month to flyFebruary
Average flight time13 hrs, 29 mins
Average flights per week272
Most popular airlineIberia

Frequently asked questions

Yes - direct flights currently operate from Madrid Airport to Santiago Arturo Merino Benitez Airport in Santiago Metropolitan Region.
We looked at all of the upcoming return flights from Madrid Airport to Santiago Metropolitan Region we could find over the next 12 months. It looks like 649 € is the best price. This is good, compared to the average Santiago Metropolitan Region ticket price of 649 €.
The cheapest month to fly from Madrid Airport to Santiago Metropolitan Region is currently February.
After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Madrid Airport to Santiago Metropolitan Region on Tuesday, 3 February 2026.
If you're flying from Madrid, the cheapest city in Santiago Metropolitan Region to fly into is Santiago. The cheapest airport serving Santiago at the moment is Santiago Arturo Merino Benitez.
The average flight time between Madrid Airport and Santiago Metropolitan Region is 13 hours and 29 minutes.