Cheap Flights from Santa Ana John Wayne Airport to South Carolina from 235 € Return

Flight deals from Santa Ana John Wayne Airport to South Carolina

Looking for cheap tickets from Santa Ana John Wayne Airport to South Carolina, or a last-minute trip? Find the lowest prices on one-way and return tickets right here.

Charleston.235 € per passenger.Departing Sat, 6 Dec, returning Tue, 6 Jan.Return flight with Frontier Airlines and Breeze Airways.Outbound indirect flight with Frontier Airlines, departs from Santa Ana John Wayne on Sat, 6 Dec, arriving in Charleston.Inbound indirect flight with Breeze Airways, departs from Charleston on Tue, 6 Jan, arriving in Santa Ana John Wayne.Price includes taxes and charges.From 235 €, select.

Greenville.275 € per passenger.Departing Tue, 18 Nov, returning Sat, 22 Nov.Return flight with Spirit Airlines and Allegiant Air.Outbound indirect flight with Spirit Airlines, departs from Santa Ana John Wayne on Tue, 18 Nov, arriving in Greenville-Spartanburg.Inbound indirect flight with Allegiant Air, departs from Greenville-Spartanburg on Sat, 22 Nov, arriving in Santa Ana John Wayne.Price includes taxes and charges.From 275 €, select.

Myrtle Beach.281 € per passenger.Departing Wed, 10 Dec, returning Tue, 16 Dec.Return flight with Frontier Airlines and Spirit Airlines.Outbound indirect flight with Frontier Airlines, departs from Santa Ana John Wayne on Wed, 10 Dec, arriving in Myrtle Beach International .Inbound indirect flight with Spirit Airlines, departs from Myrtle Beach International on Tue, 16 Dec, arriving in Santa Ana John Wayne.Price includes taxes and charges.From 281 €, select.

Columbia.671 € per passenger.Departing Sun, 21 Dec, returning Mon, 29 Dec.Return flight with United.Outbound indirect flight with United, departs from Santa Ana John Wayne on Sun, 21 Dec, arriving in Columbia Metropolitan.Inbound indirect flight with United, departs from Columbia Metropolitan on Mon, 29 Dec, arriving in Santa Ana John Wayne.Price includes taxes and charges.From 671 €, select.

See more deals

Flying from Santa Ana John Wayne Airport to South Carolina

Arm yourself with these facts on the fly.

Cheapest flight found	235 €
Cheapest month to fly	December

How to find cheap flights from Santa Ana John Wayne Airport to South Carolina

We've compared the best online travel agents and flight providers on the internet to find the cheapest plane tickets from Santa Ana John Wayne Airport to South Carolina. Other savvy travellers recently found return flights from 235 € and one-way tickets from 133 €. Ready to join them? Here are a few tips to help you do it the smart way.

Fly in December

The cheapest time to fly from Santa Ana John Wayne Airport to South Carolina is currently December.

Flex your dates for the best rates

If you’re flexible on your departure dates, you can use Skyscanner's whole month tool to find the cheapest day of the year to fly from Santa Ana John Wayne Airport to anywhere you choose in South Carolina.

Watch as fares rise and fall

With Price Alerts, we'll let you know when flight prices from Santa Ana John Wayne Airport to your chosen airport in South Carolina go up or down so you can book when the time is just right.

Relax – these are fee-free flight tickets

With us, there are no added fees – the South Carolina Airport to South Carolina flight price you see when you search with us is what you pay to the provider.

Frequently asked questions

Are there any direct flights from Santa Ana John Wayne Airport to South Carolina?

There are currently no direct flights from Santa Ana John Wayne Airport to South Carolina, but we've found some other routes to United States – check them out now.

What is the average price of a flight from Santa Ana John Wayne Airport to South Carolina?

We looked at all of the upcoming return flights from Santa Ana John Wayne Airport to South Carolina we could find over the next 12 months. It looks like 235 € is the best price. This is good, compared to the average South Carolina ticket price of 366 €.

What is the cheapest month to fly from Santa Ana John Wayne Airport to South Carolina?

The cheapest month to fly from Santa Ana John Wayne Airport to Charleston Airport is currently December.
The cheapest month to fly from Santa Ana John Wayne Airport to Columbia Metropolitan Airport is currently December.
The cheapest month to fly from Santa Ana John Wayne Airport to Greenville-Spartanburg Airport is currently November.
And the cheapest month to fly from Santa Ana John Wayne Airport to Myrtle Beach International Airport is usually December.

Which upcoming date is cheapest to fly from Santa Ana John Wayne Airport to South Carolina on?

After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Santa Ana John Wayne Airport to South Carolina on Saturday, 6 December 2025.

If I'm flying from Santa Ana John Wayne Airport, where in South Carolina is cheapest to fly into?

If you're flying from Santa Ana John Wayne, the cheapest city in South Carolina to fly into is Charleston. The cheapest airport serving Charleston at the moment is Charleston.