394 € Cheap Flights from Denver to Panama City

Compare Denver to Panama City flight deals

Find the cheapest month or even day of the year to fly to Panama City

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Flight deals from Denver to Panama City

Looking for a cheap last-minute deal or the best return flight from Denver to Panama City? Find the lowest prices on one-way and return tickets right here.

Find the cheapest month to fly from Denver to Panama City

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Denver to Panama City flights are currently cheapest in April.

Direct flights from Denver to Panama City

Alternative Denver to Panama City routes

Looking for the cheapest, fastest or easiest route from Denver to Panama City? You could fly into the following airports instead.

Denver to Panama City: Flight information

The things to know before you go.
Cheapest flight found394 €
Cheapest month to flyApril
Average flight time5 hrs, 48 mins
Most popular airlineCopa
Average flights per week15

Finding cheap flights from Denver to Panama City: Frequently asked questions

There are 3 airports in Panama City: Panama City Paitilla, Balboa and Panama City Tocumen International.
The best price we found for a return flight from Denver to Panama City is 394 €. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
5 hours and 48 minutes is the average flight time from Denver to Panama City.
Copa and United fly direct from Denver to Panama City.
As of February 2026, there are 15 flights per week flying from Denver to Panama City.
The cheapest month to fly from Denver to Panama City is usually April.
If you're flying from Denver, the cheapest airport near Panama City is Panama City Tocumen International – which is 17.9 km away from the centre of Panama City. We've found flights into this airport from 394 €.
After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Denver to Panama City on Monday, 20 April 2026.
Yes – the average flight time is 5 hours and 48 minutes.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Panama City but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Panama City is around 40 days in advance, so don’t leave your flight to the last minute.
In February, the average temperature is usually around 27°C. May is typically the warmest month in Panama City, when it usually averages around 29°C. You can expect the least rain in February. The coldest month is October, with temperatures averaging 25°C. The rainiest month is June.
The cheapest airline that flies to Panama City is Frontier Airlines. And the cheapest airline that flies to Balboa Airport is Copa.

Flying from Denver to Panama City: what you need to know

  • Denver International Airport (DEN) is Denver's main airport. Explore your options for reserving a flight from Denver to Panama City leaving from here.

  • Step off your plane in Panama City at Tocumen International Airport (PTY) or Panama Pacifico Airport (BLB).

  • The average time for a direct Denver to Panama City flight is 5 hours 50 minutes.

  • Panama City's timezone is UTC-5, making Panama City one hour ahead of Denver.

  • Denver International Airport (DEN) to Tocumen International Airport (PTY) is the most popular route that connects these two cities. There are six weekly flights to choose from. If you prefer starting your day later, the last flight from Denver to Panama City is with Copa Airlines at 22:26. Opt for the first DEN to PTY departure with Copa Airlines at 20:19 to make the most of your arrival in Panama City.

  • To ensure you make your Denver to Panama City flight, leave plenty of time to navigate the airport and find your gate. Turning up two hours ahead of international departures and an hour before domestic flights is the standard rule.

  • Be prepared for longer lines during popular months like July. Arriving up to four hours in advance for international flights and two hours for a domestic departure is a wise move.

How to find the cheapest flights from Denver to Panama City

  • The lowest price we've found for a one-way ticket from Denver to Panama City is 163 €. For a return flight on this route, the best price is 394 €. Depending on the availability when you book, these fares may change.

  • Book two months before you want to travel. Pricing trends suggest that this is the ideal window for finding cheap Denver to Panama City flights.

  • Plan your trip for May. That's the best month for landing an awesome deal on plane tickets from Denver to Panama City. If you have flexibility with your dates, use the 'Whole month' tool to find the lowest price across every month.

  • Getting a cheap flight from Denver to Panama City is a piece of cake with Price Alerts. Simply set up one of these automatic alerts and we'll notify you when a better deal is available.

  • Pick your ideal arrival and departure times, number of stops and airlines by using the filters. Or sort your Denver to Panama City flight results by 'Best,' 'Fastest' or 'Cheapest.'

Flying from Denver

Denver International Airport (DEN)

  • You can catch a direct flight from Denver to Panama City leaving from Denver International Airport (DEN). Begin your journey at DEN and arrive at Tocumen International Airport (PTY).

  • Copa Airlines is a well-known airline that offers direct Denver to Panama City plane tickets from DEN.

  • We make it simple to find a Denver to Panama City flight with a stopover. To see all your options leaving from Denver International Airport, deselect 'Direct flights only.' Then, select a flight that has a stop long enough to explore your chosen city. Top stopovers include:

    • George Bush Intercontinental Airport (IAH)

    • Orlando International Airport (MCO)

    • Cancun International Airport (CUN)

  • The journey from central Denver to DEN takes around 1 hour 30 minutes by public transport. If you ride-share, drive or take a cab, you'll cover the 31 kilometres in 35 minutes or so, depending on traffic conditions.

  • In search of a hotel to stay at before your flight from Denver to Panama City? Consider Baymont by Wyndham Denver International Airport. Enjoy a good night's sleep here before making your way to Denver International Airport.

  • Denver International Airport maintains a strong on-time performance, reducing your chances of a delayed flight. Departures from DEN make it to their destination as scheduled 80.23% of the time.

  • DEN's address is 8500 Pena Boulevard.

Arriving in Panama City

Tocumen International Airport (PTY)

  • The distance from Tocumen International Airport (PTY) to central Panama City is approximately 16 kilometres. It takes about 20 minutes to reach the centre driving.

  • Getting there on public transport will take you around 1 hour 5 minutes.

  • Book a hotel close to PTY if you're coming in on a late flight from Denver to Panama City. Check in to one of these options and avoid the hassle of a long transfer:

  • Pick up a Tocumen International Airport rental car and explore Panama City and beyond with your own set of wheels. Avis, Dollar and MEX are popular outlets to choose from here.

  • Reserving your ride from Tocumen International Airport about three weeks in advance can help you secure the lowest rate.

Marcos A. Gelabert International Airport (PAC)

  • After your flight from Denver to Panama City has arrived, you can reach the city centre in around 5 minutes by car. Central Panama City is roughly 2 kilometres from Marcos A. Gelabert International Airport (PAC).

  • If you're travelling on public transport, it'll take about 25 minutes.

  • Hang the 'Do not disturb' sign on your door and unwind at a hotel close to BLB. Here are a few options where you can kick back after your flight from Denver to Panama City:

  • Forget about public transport schedules or long cab queues. Pick up a Marcos A. Gelabert International Airport rental car and blaze your own trail. Compare availability and rates from Thrifty, Avis and Alamo.

  • Avoid last-minute price surges. Reserving your ride three weeks before your arrival at PAC can get you a lower rate.

Panama Pacifico Airport (BLB)

  • Make your way to the city centre after your flight from Denver to Panama City has arrived. Central Panama City is around 11 kilometres from Panama Pacifico Airport (BLB) and takes roughly 20 minutes to get there in a car.

  • Begin your journey without stressing over how to get to where you're going with a Panama Pacifico Airport rental car. You can book with trusted companies here like Sixt, Dollar and Thrifty.

  • Around one week ahead of your flight from Denver to Panama City is a good time to book your ride from BLB. You're likely to find a better rate or even pick up some early bird discounts.

Best time to go to Panama City

  • June is the busiest month for flights from Denver to Panama City. To steer clear of the crowds, visit Panama City in February.

  • Before locking in your Denver to Panama City tickets, consider the kind of weather you prefer. March is the warmest month in Panama City, with temperatures ranging from 21ºC (70ºF) to 32ºC (90ºF).

  • February sees average temperatures of between 22ºC (72ºF) and 31ºC (88ºF). Search for cheap flights from Denver to Panama City around that time if you want to travel when it's cooler.

More about Panama City

  • Start your Panama City trip right by choosing the ideal place to stay. Once you've booked your flight from Denver to Panama City, check out our selection of accommodation options including:

  • There are so many things to see and do in this city it can be hard to work out where to start. Panama Canal Museum, Casco Viejo and Cinta Costera are top sights which should feature on any well-planned Panama City itinerary.

Explore more of Panama

  • San Miguelito is just one of the many cities in Panama waiting to be explored after you've experienced Panama City. Around 6 kilometres to the north, top sights here include Iglesia Cristo Luz del Mundo, IDMJI SAN MIGUELITO and Iglesia Bautista Independiente Emanuel.

  • Around 11 kilometres north-east of Panama City, Juan Díaz is another favourite stop in Panama. Experience major highlights starting with Malecon Costa Del Este, El Patio Human Friendly and Parque Los Robles Sur.

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.