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185 € Cheap Flights from Des Moines to San Diego

Compare Des Moines to San Diego flight deals

Find the cheapest month or even day of the year to fly to San Diego

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Flight deals from Des Moines Airport to San Diego

Looking for a cheap last-minute deal or the best return flight from Des Moines Airport to San Diego? If you want to travel next month, return fares start from 185 €. Find the lowest prices on one-way and return tickets right here.
San Diego.185 € per passenger.Departing Sat, 4 Apr, returning Thu, 9 Apr.Return flight with Allegiant Air and Frontier Airlines.Outbound indirect flight with Allegiant Air, departs from Des Moines on Sat, 4 Apr, arriving in San Diego International.Inbound indirect flight with Frontier Airlines, departs from San Diego International on Thu, 9 Apr, arriving in Des Moines.Price includes taxes and charges.From 185 €, select.
San Diego.211 € per passenger.Departing Fri, 8 May, returning Sat, 9 May.Return flight with Frontier Airlines.Outbound indirect flight with Frontier Airlines, departs from Des Moines on Fri, 8 May, arriving in San Diego International.Inbound indirect flight with Frontier Airlines, departs from San Diego International on Sat, 9 May, arriving in Des Moines.Price includes taxes and charges.From 211 €, select.
San Diego.211 € per passenger.Departing Fri, 27 Mar, returning Mon, 30 Mar.Return flight with Frontier Airlines.Outbound indirect flight with Frontier Airlines, departs from Des Moines on Fri, 27 Mar, arriving in San Diego International.Inbound indirect flight with Frontier Airlines, departs from San Diego International on Mon, 30 Mar, arriving in Des Moines.Price includes taxes and charges.From 211 €, select.
San Diego.235 € per passenger.Departing Mon, 22 Jun, returning Mon, 29 Jun.Return flight with Allegiant Air and Frontier Airlines.Outbound indirect flight with Allegiant Air, departs from Des Moines on Mon, 22 Jun, arriving in San Diego International.Inbound indirect flight with Frontier Airlines, departs from San Diego International on Mon, 29 Jun, arriving in Des Moines.Price includes taxes and charges.From 235 €, select.
San Diego.243 € per passenger.Departing Thu, 26 Mar, returning Sun, 5 Apr.Return flight with Allegiant Air and Frontier Airlines.Outbound indirect flight with Allegiant Air, departs from Des Moines on Thu, 26 Mar, arriving in San Diego International.Inbound indirect flight with Frontier Airlines, departs from San Diego International on Sun, 5 Apr, arriving in Des Moines.Price includes taxes and charges.From 243 €, select.
San Diego.246 € per passenger.Departing Mon, 6 Jul, returning Fri, 10 Jul.Return flight with Allegiant Air and Frontier Airlines.Outbound indirect flight with Allegiant Air, departs from Des Moines on Mon, 6 Jul, arriving in San Diego International.Inbound indirect flight with Frontier Airlines, departs from San Diego International on Fri, 10 Jul, arriving in Des Moines.Price includes taxes and charges.From 246 €, select.
San Diego.273 € per passenger.Departing Sun, 7 Jun, returning Sun, 2 Aug.Return flight with Allegiant Air and Frontier Airlines.Outbound indirect flight with Allegiant Air, departs from Des Moines on Sun, 7 Jun, arriving in San Diego International.Inbound indirect flight with Frontier Airlines, departs from San Diego International on Sun, 2 Aug, arriving in Des Moines.Price includes taxes and charges.From 273 €, select.
San Diego.294 € per passenger.Departing Wed, 29 Apr, returning Mon, 4 May.Return flight with Southwest Airlines.Outbound indirect flight with Southwest Airlines, departs from Des Moines on Wed, 29 Apr, arriving in San Diego International.Inbound indirect flight with Southwest Airlines, departs from San Diego International on Mon, 4 May, arriving in Des Moines.Price includes taxes and charges.From 294 €, select.
San Diego.342 € per passenger.Departing Mon, 19 Oct, returning Tue, 27 Oct.Return flight with Southwest Airlines.Outbound indirect flight with Southwest Airlines, departs from Des Moines on Mon, 19 Oct, arriving in San Diego International.Inbound indirect flight with Southwest Airlines, departs from San Diego International on Tue, 27 Oct, arriving in Des Moines.Price includes taxes and charges.From 342 €, select.
San Diego.355 € per passenger.Departing Wed, 25 Nov, returning Mon, 30 Nov.Return flight with Delta.Outbound indirect flight with Delta, departs from Des Moines on Wed, 25 Nov, arriving in San Diego International.Inbound indirect flight with Delta, departs from San Diego International on Mon, 30 Nov, arriving in Des Moines.Price includes taxes and charges.From 355 €, select.

Find the cheapest month to fly from Des Moines to San Diego

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Des Moines to San Diego flights are currently cheapest in April.
Mar
from 211 €
Apr
from 185 €
May
from 211 €
Jun
from 235 €
Jul
from 246 €
Aug
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Sep
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Oct
from 342 €
Nov
from 355 €
Dec
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Jan
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Feb
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Alternative Des Moines to San Diego routes

Looking for the cheapest, fastest or easiest route from Des Moines to San Diego? You could fly into the following airports instead.

San Diego International

4km from central San Diego
ClosestCheapest
from 185 €
Search flights

McClellan-Palomar

48km from central San Diego
from 914 €
Search flights

Des Moines to San Diego: Flight information

The things to know before you go.
Cheapest flight found185 €
Cheapest month to flyApril

Finding cheap flights from Des Moines to San Diego: Frequently asked questions

There are 2 airports in San Diego: San Diego International and McClellan-Palomar.
The best price we found for a return flight from Des Moines to San Diego is 185 €. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Des Moines to San Diego. But we found flights with one or more stops from 185 €.
As of March 2026, there are no flights flying from Des Moines to San Diego.
The cheapest month to fly from Des Moines to San Diego is usually April.
If you're flying from Des Moines Airport, the cheapest airport near San Diego is San Diego International – which is 4.1 km away from the centre of San Diego. We've found flights into this airport from 185 €.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Des Moines Airport to San Diego on Saturday, 4 April 2026.
No airlines currently offer direct flights between Des Moines Airport and San Diego. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to San Diego but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to San Diego is around 40 days in advance, so don’t leave your flight to the last minute.
In March, the average temperature is usually around 14°C. August is typically the warmest month in San Diego, when it usually averages around 28°C. You can expect the least rain in June. The coldest month is December, with temperatures averaging 10°C. The rainiest month is February.
Currently, Allegiant Air offers the cheapest flight tickets to San Diego.

Flying from Des Moines International Airport (DSM) to San Diego: what you need to know

  • Around 3 hours 30 minutes is how long you can expect to be travelling on a direct flight from Des Moines International Airport to San Diego.

  • San Diego is two hours behind Des Moines, where Des Moines International Airport is located. San Diego follows the UTC-7 timezone.

  • For a stress-free journey, arrive at the airport two hours ahead of international flights and one hour before domestic departures. This ensures you have enough time to board your DSM to San Diego flight.

  • Delays at check-in and security are more likely if you're travelling during high season, so allow even more breathing space. A good rule for peak times? Get there up to four hours ahead for international flights and two hours for domestic departures.

  • You can book a direct Des Moines International Airport to San Diego ticket. Begin your journey at DSM and land at San Diego International Airport (SAN).

  • Book your seat with Allegiant Air. This leading carrier operates direct flights from Des Moines International Airport to San Diego.

  • Located around 6 kilometres from the centre of Des Moines, DSM can be reached in about 15 minutes by car (depending on traffic). The journey on public transport takes roughly 45 minutes.

  • Have an early flight from Des Moines International Airport to San Diego? Avoid the stress of rushing to the airport (and enjoy a little extra shut-eye) by choosing one of these stays close to DSM:

  • 80.45% of flights leaving Des Moines International Airport reach their destination on time. With its strong on-time stats, you're unlikely to face delays when setting off from DSM.

  • The address for DSM is 5800 Fleur Drive, Suite 201.

How to find the cheapest flights from Des Moines International Airport (DSM) to San Diego

  • 74 € is the cheapest price we've seen for a one-way Des Moines International Airport to San Diego flight. A round-trip plane ticket right now is 185 €. Depending on when you want to go and the availability, these fares may change.

  • To pick up cheap flights from DSM to San Diego, reserve your journey one month ahead of your departure date.

  • Schedule your trip for May. That's the best month for scoring an awesome deal on Des Moines International Airport to San Diego tickets. If you're flexible with your travel dates, use the 'Whole month' tool to access the cheapest price across each month.

  • There's no need to check back in every day to see if fares have dropped when you create a Price Alert. We'll notify you when there's an extra saving on cheap flights from DSM to San Diego.

  • Select your ideal departure and arrival times, airlines and number of stops with our filters. Then, sort the results for your flight from Des Moines International Airport to San Diego by 'Best,' 'Cheapest' or 'Fastest.'

Airports in San Diego

San Diego International Airport (SAN)

  • The distance from San Diego International Airport (SAN) to central San Diego is roughly 5 kilometres. It'll take you about 10 minutes to reach the centre driving.

  • Getting to the centre by public transport will take you around 20 minutes.

  • If you have a late flight from Des Moines International Airport to San Diego, nothing beats the convenience of staying near the terminal. Grab your bags from the carousel and then be showered and relaxing soon after at one of these accommodation options near SAN:

  • Travel at your own pace with a San Diego International Airport rental car. Book your wheels from Thrifty, Dollar or Budget and see more of San Diego and beyond.

  • To get the lowest price, book your vehicle from San Diego International Airport about two weeks in advance of your flight from DSM to San Diego.

  • SAN is located at N Harbour Dr.

McClellan-Palomar Airport (CLD)

  • Once your flight from Des Moines International Airport to San Diego has hit the tarmac, you can reach the city centre in around 40 minutes by car. Central San Diego is roughly 56 kilometres from McClellan-Palomar Airport (CLD).

  • The journey will take about 2 hours 15 minutes on public transport.

  • You'll find some great places ready to welcome you near CLD. Unwind and get cosy after your DSM to San Diego flight at one of these well-located options:

  • Forget about public transport timetables or waiting in a long cab line. Pick up a McClellan-Palomar Airport rental car and let the journey unfold your way. Compare offers from Budget, Hertz and Avis.

  • Get the vehicle you actually want, not just what's available, by booking your ride from CLD in advance. You'll also avoid last-minute price hikes, especially during busy airport times.

Best time to go to San Diego

  • Carefully consider your trip dates before securing your flight from Des Moines International Airport to San Diego. The city comes alive in high season, but rates are typically higher and attractions can get crowded. Visit San Diego in the low season if you like a quieter vibe.

  • The warmest month in San Diego is August, with temperatures ranging between 17ºC (63ºF) and 28ºC (82ºF). Lock in your Des Moines International Airport to San Diego plane ticket then if this is the type of weather you enjoy.

  • If you'd rather travel in cooler conditions, search for a cheap ticket from DSM to San Diego in February when temperatures average between 7ºC (45ºF) and 23ºC (73ºF).

More about San Diego

  • When it comes to looking for somewhere to lay your head, you'll find the best places to stay in San Diego right here. Explore these options once you've booked your flight from Des Moines International Airport to San Diego:

  • Every great adventure has to include a little sightseeing. USS Midway Museum, San Diego Zoo and SeaWorld San Diego are must-do's during your San Diego adventure.

Explore more of United States

  • You've visited San Diego, now it's time to explore other corners of United States. Travel around 177 kilometres north-west to Los Angeles to check off its leading sights. From Griffith Observatory to The Broad and La Brea Tar Pits & Museum, you've got a jam-packed schedule ahead.

  • Around 483 kilometres east of San Diego, Phoenix is another essential stop in United States. No visit is complete without checking out Desert Botanical Garden, Heard Museum and Papago Park.

Plan the rest of your trip from Des Moines to San Diego

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.