254 € Cheap Flights from Mexico City to Panama City

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Compare Mexico City to Panama City flight deals

Find the cheapest month or even day of the year to fly to Panama City

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Flight deals from Mexico City to Panama City

Looking for a cheap last-minute deal or the best return flight from Mexico City to Panama City? If you want to travel next month, return fares start from 290 €. Find the lowest prices on one-way and return tickets right here.

Panama City.254 € per passenger.Departing Fri, 25 Dec, returning Thu, 31 Dec.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Mexico City Juarez International on Fri, 25 Dec, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Thu, 31 Dec, arriving in Mexico City Juarez International.Price includes taxes and charges.From 254 €, select.

Panama City.284 € per passenger.Departing Wed, 3 Feb, returning Sat, 20 Feb.Return flight with Aeromexico.Outbound direct flight with Aeromexico departs from Mexico City Juarez International on Wed, 3 Feb, arriving in Panama City Tocumen International.Inbound direct flight with Aeromexico departs from Panama City Tocumen International on Sat, 20 Feb, arriving in Mexico City Juarez International.Price includes taxes and charges.From 284 €, select.

Panama City.290 € per passenger.Departing Thu, 1 Oct, returning Wed, 14 Oct.Return flight with Aeromexico.Outbound direct flight with Aeromexico departs from Mexico City Juarez International on Thu, 1 Oct, arriving in Panama City Tocumen International.Inbound direct flight with Aeromexico departs from Panama City Tocumen International on Wed, 14 Oct, arriving in Mexico City Juarez International.Price includes taxes and charges.From 290 €, select.

Panama City.292 € per passenger.Departing Thu, 24 Dec, returning Wed, 30 Dec.Return flight with Copa.Outbound direct flight with Copa departs from Mexico City Juarez International on Thu, 24 Dec, arriving in Panama City Tocumen International.Inbound direct flight with Copa departs from Panama City Tocumen International on Wed, 30 Dec, arriving in Mexico City Juarez International.Price includes taxes and charges.From 292 €, select.

Panama City.304 € per passenger.Departing Tue, 22 Sep, returning Sun, 4 Oct.Return flight with Copa.Outbound direct flight with Copa departs from Mexico City Juarez International on Tue, 22 Sep, arriving in Panama City Tocumen International.Inbound direct flight with Copa departs from Panama City Tocumen International on Sun, 4 Oct, arriving in Mexico City Juarez International.Price includes taxes and charges.From 304 €, select.

Panama City.304 € per passenger.Departing Sun, 22 Nov, returning Sun, 29 Nov.Return flight with Copa.Outbound direct flight with Copa departs from Mexico City Juarez International on Sun, 22 Nov, arriving in Panama City Tocumen International.Inbound direct flight with Copa departs from Panama City Tocumen International on Sun, 29 Nov, arriving in Mexico City Juarez International.Price includes taxes and charges.From 304 €, select.

Panama City.304 € per passenger.Departing Tue, 22 Sep, returning Tue, 29 Sep.Return flight with Copa.Outbound direct flight with Copa departs from Mexico City Juarez International on Tue, 22 Sep, arriving in Panama City Tocumen International.Inbound direct flight with Copa departs from Panama City Tocumen International on Tue, 29 Sep, arriving in Mexico City Juarez International.Price includes taxes and charges.From 304 €, select.

Panama City.305 € per passenger.Departing Mon, 16 Nov, returning Sat, 5 Dec.Return flight with Copa.Outbound direct flight with Copa departs from Mexico City Juarez International on Mon, 16 Nov, arriving in Panama City Tocumen International.Inbound direct flight with Copa departs from Panama City Tocumen International on Sat, 5 Dec, arriving in Mexico City Juarez International.Price includes taxes and charges.From 305 €, select.

Panama City.305 € per passenger.Departing Mon, 26 Oct, returning Mon, 2 Nov.Return flight with Copa.Outbound direct flight with Copa departs from Mexico City Juarez International on Mon, 26 Oct, arriving in Panama City Tocumen International.Inbound direct flight with Copa departs from Panama City Tocumen International on Mon, 2 Nov, arriving in Mexico City Juarez International.Price includes taxes and charges.From 305 €, select.

Panama City.311 € per passenger.Departing Thu, 24 Dec, returning Sat, 9 Jan.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Mexico City Juarez International on Thu, 24 Dec, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Sat, 9 Jan, arriving in Mexico City Juarez International.Price includes taxes and charges.From 311 €, select.

Panama City.312 € per passenger.Departing Fri, 1 Jan, returning Mon, 11 Jan.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Mexico City Juarez International on Fri, 1 Jan, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Mon, 11 Jan, arriving in Mexico City Juarez International.Price includes taxes and charges.From 312 €, select.

Panama City.315 € per passenger.Departing Thu, 28 Jan, returning Sat, 6 Feb.Return flight with Aeromexico.Outbound direct flight with Aeromexico departs from Mexico City Juarez International on Thu, 28 Jan, arriving in Panama City Tocumen International.Inbound direct flight with Aeromexico departs from Panama City Tocumen International on Sat, 6 Feb, arriving in Mexico City Juarez International.Price includes taxes and charges.From 315 €, select.

Panama City.318 € per passenger.Departing Fri, 1 Jan, returning Mon, 11 Jan.Return flight with Copa.Outbound direct flight with Copa departs from Mexico City Juarez International on Fri, 1 Jan, arriving in Panama City Tocumen International.Inbound direct flight with Copa departs from Panama City Tocumen International on Mon, 11 Jan, arriving in Mexico City Juarez International.Price includes taxes and charges.From 318 €, select.

Panama City.318 € per passenger.Departing Thu, 31 Dec, returning Tue, 12 Jan.Return flight with Copa.Outbound direct flight with Copa departs from Mexico City Juarez International on Thu, 31 Dec, arriving in Panama City Tocumen International.Inbound direct flight with Copa departs from Panama City Tocumen International on Tue, 12 Jan, arriving in Mexico City Juarez International.Price includes taxes and charges.From 318 €, select.

Panama City.339 € per passenger.Departing Sun, 11 Oct, returning Mon, 14 Dec.Return flight with Copa.Outbound direct flight with Copa departs from Mexico City Juarez International on Sun, 11 Oct, arriving in Panama City Tocumen International.Inbound direct flight with Copa departs from Panama City Tocumen International on Mon, 14 Dec, arriving in Mexico City Juarez International.Price includes taxes and charges.From 339 €, select.

Panama City.339 € per passenger.Departing Sat, 27 Feb, returning Sat, 6 Mar.Return flight with Copa.Outbound direct flight with Copa departs from Mexico City Juarez International on Sat, 27 Feb, arriving in Panama City Tocumen International.Inbound direct flight with Copa departs from Panama City Tocumen International on Sat, 6 Mar, arriving in Mexico City Juarez International.Price includes taxes and charges.From 339 €, select.

Find the cheapest month to fly from Mexico City to Panama City

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Mexico City to Panama City flights are currently cheapest in December.

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Direct flights from Mexico City to Panama City

Alternative Mexico City to Panama City routes

Looking for the cheapest, fastest or easiest route from Mexico City to Panama City? You could fly into the following airports instead.

Mexico City to Panama City: Flight information

The things to know before you go.

Cheapest flight found	254 €
Cheapest month to fly	December
Average flight time	3 hrs, 50 mins
Most popular airline	Copa
Average flights per week	89

Finding cheap flights from Mexico City to Panama City: Frequently asked questions

How many airports are there in Panama City?

There are 3 airports in Panama City: Panama City Paitilla, Balboa and Panama City Tocumen International.

How much are return flights from Mexico City to Panama City?

The best price we found for a return flight from Mexico City to Panama City is 254 €. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

How long does it take to fly from Mexico City to Panama City?

3 hours and 49 minutes is the average flight time from Mexico City to Panama City.

Which airlines fly direct from Mexico City to Panama City?

Copa, Emirates and Aeromexico fly direct from Mexico City to Panama City.

How many flights are there a week from Mexico City to Panama City?

As of September 2026, there are 412 flights per week flying from Mexico City to Panama City.

When is the cheapest time to fly from Mexico City to Panama City?

The cheapest month to fly from Mexico City to Panama City is usually December.

Which is the cheapest airport to fly into in Panama City?

If you're flying from Mexico City, the cheapest airport near Panama City is Panama City Tocumen International – which is 17.9 km away from the centre of Panama City. We've found flights into this airport from 254 €.

Which upcoming date is cheapest to fly from Mexico City to Panama City on?

After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Mexico City to Panama City on Friday, 25 December 2026.

Can I get a direct flight from Mexico City to Panama City?

Yes – the average flight time is 3 hours and 48 minutes.

How can I get the best flight deal from Mexico City to Panama City?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Panama City but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to Panama City?

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Panama City is around 40 days in advance, so don’t leave your flight to the last minute.

What’s the weather like in Panama City?

In September, the average temperature is usually around 27°C. May is typically the warmest month in Panama City, when it usually averages around 29°C. You can expect the least rain in February. The coldest month is November, with temperatures averaging 25°C. The rainiest month is July.

Which is the cheapest airline to fly from Mexico City to Panama City with?

The cheapest airline that flies to Panama City is Avianca. And the cheapest airline that flies to Balboa Airport is Aeromexico.

Travelling from Mexico City to Panama City: what you need to know

Mexico City is home to a couple of airports where you can start your adventure. Explore your options for reserving a flight from Mexico City to Panama City flying out of Mexico City Juarez International Airport (MEX) or Felipe Angeles International Airport (NLU).
Touch down in Panama City at Panama City Tocumen International Airport (PTY) or Balboa Airport (BLB).
Around 3 hours 45 minutes is how long you'll be travelling on a direct Mexico City to Panama City flight.
Panama City's timezone is UTC-5, making Panama City one hour ahead of Mexico City.
Mexico City Juarez International Airport (MEX) to Panama City Tocumen International Airport (PTY) is the most traveled route that connects these two cities. There are 46 departures a week to choose from. If you prefer starting your day later, the last flight from Mexico City to Panama City is with Copa Airlines at 15:35. Opt for the first MEX to PTY departure with Copa Airlines at 01:20 to maximise your time in Panama City.
For stress-free travel, arrive at the airport two hours ahead of international flights and an hour before domestic departures. This leaves you with plenty of time to board your Mexico City to Panama City flight.
During popular months like June, it's best to get to the airport well in advance. Plan to arrive two hours before a domestic departure and four hours ahead of international flights whenever you're travelling during peak periods in general.

How to find the cheapest flights from Mexico City to Panama City

To score cheap Mexico City to Panama City flights, book your journey five months before your departure date.
The best month for landing cheap plane tickets from Mexico City to Panama City is October. Use the 'Whole month' tool to compare all available prices, then choose the dates that offer the biggest savings.
Save time looking for cheap flights from Mexico City to Panama City by creating a Price Alert. We'll send you an email or notification on the app when a new discounted fare appears.
Select your preferred departure and arrival times, number of stops and airlines with the filters. Alternatively, sort your Mexico City to Panama City flight results by 'Fastest,' 'Best' or 'Cheapest.'

Flying from Mexico City

Mexico City Juarez International Airport (MEX)

Set off from Mexico City Juarez International Airport (MEX) on a nonstop flight from Mexico City to Panama City. From MEX, you can fly directly to Panama City Tocumen International Airport (PTY).
Copa Airlines is a leading airline that offers direct Mexico City to Panama City plane tickets from MEX.
Consider adding a stopover to potentially save on your Mexico City to Panama City flight. Just deselect 'Direct flights only' when browsing departures from Mexico City Juarez International Airport. Take a break (and maybe save some cash) by stopping at one of these popular options:
- Bogota Airport (BOG)
- Cancun Airport (CUN)
- Guadalajara Airport (GDL)
MEX is about 6 kilometres from central Mexico City. If you're driving, ride-sharing or catching a taxi from the centre, it'll take 30 minutes or so to get there, depending on traffic conditions. If you're taking public transport, expect the trip time to be around 40 minutes.
After a relaxed start to your trip? Stay near Mexico City Juarez International Airport. Whether you're catching an early flight from Mexico City to Panama City or just don't want to be rushed, these hotels are ideal:
84% of flights leaving Mexico City Juarez International Airport reach their destination on time. Given its dependable on-time performance, you're unlikely to be delayed when jetting out of MEX.

Felipe Angeles International Airport (NLU)

Get more out of your holiday with a stopover on your Mexico City to Panama City flight. Visit family or friends or tick a new city off your list. Whatever you want to do, check out these stops between Felipe Angeles International Airport and Panama City:
- Bogota Airport (BOG)
- Cancun Airport (CUN)
- Guadalajara Airport (GDL)
You can reach NLU from central Mexico City in about 55 minutes by car (depending on traffic). The ride by public transport takes roughly 2 hours to travel the 40 kilometres or so.
Start your holiday sooner with an extra night away from home. Before your flight from Mexico City to Panama City, unwind in one of these hotels close to Felipe Angeles International Airport:
Felipe Angeles International Airport has an on-time performance of 76%. This figure sheds light on how often flights that take off from this airport arrive on time.

Arriving in Panama City

Panama City Tocumen International Airport (PTY)

Panama City Tocumen International Airport (PTY) is approximately 18 kilometres from central Panama City. If you're catching a taxi or a ride-share, the drive will take around 35 minutes.
Travelling to the centre by public transport takes about 50 minutes.
The last thing you need is a long journey to your hotel if you're arriving on a late flight from Mexico City to Panama City. Check in to one of these accommodation options near PTY instead:
Follow your own route with a Panama City Tocumen International Airport rental car. Pick up a set of wheels from Avis, Dollar or MEX and discover more of Panama City and beyond.
Lock in the lowest price by booking your ride from Panama City Tocumen International Airport around three weeks before your trip.

Panama City Paitilla Airport (PAC)

Panama City Paitilla Airport (PAC) is about 5 kilometres from central Panama City. Explore your options for getting into town after your flight from Mexico City to Panama City has landed.
Hang up the 'Do not disturb' sign and rest at a hotel close to PAC. Here are a few options where you can take a load off after your flight from Mexico City to Panama City:
Forget about public transport schedules or taxi lines. Pick up a Panama City Paitilla Airport rental car and take your trip in whatever direction you choose. Compare rates and availability from Thrifty, Avis and Alamo.
Secure your first choice, not your last resort. Reserving your ride from PAC three weeks ahead of time often means better deals and a wider selection of vehicles.

Balboa Airport (BLB)

Step off your flight from Mexico City to Panama City and travel to your hotel or start taking in the sights right away. The centre of Panama City is around 5 kilometres from Balboa Airport (BLB) and takes roughly 10 minutes to reach by car.
Public transport can get you there in roughly 20 minutes.
Start your trip without worrying about how to reach your next stop with a Balboa Airport rental car. You can book a set of wheels from trusted suppliers here like Sixt, Dollar and Thrifty.
If you're searching for a specific type of vehicle, lock in your ride from BLB about one week before your flight from Mexico City to Panama City. This gives you a higher chance of getting the car you prefer, as well as a better price.

Best time to go to Panama City

March is the quietest month for flights from Mexico City to Panama City, while July is the busiest. Figure out the best time to visit Panama City based on whether you like a bustling atmosphere or a more laid-back vibe.
Lock in a Mexico City to Panama City ticket departing in March if you want to experience the city during its warmest month. Expect temperatures in Panama City to range from 21ºC (70ºF) to 32ºC (90ºF).
Look for cheap flights from Mexico City to Panama City in January if you like travelling in cooler conditions. Temperatures are at their lowest then, ranging between 22ºC (72ºF) and 31ºC (88ºF) on average.

More about Panama City

Start your Panama City trip right by choosing the perfect place to stay. After booking your flight from Mexico City to Panama City, browse our selection of hotels including:
Every great holiday has to include a little sightseeing. San Felipe, Metropolitan Cathedral Basilica of Santa Maria the Ancient and Independence Square are essential stops on your Panama City itinerary.