306 € Panama City (PTYA) to Guayaquil (GYE) Cheap Flights

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Flight deals from Panama City to Guayaquil

Looking for a cheap last-minute deal or the best return flight from Panama City to Guayaquil Airport? If you want to travel next month, return fares start from 306 €. Find the lowest prices on one-way and return tickets right here.

Guayaquil.306 € per passenger.Departing Wed, 1 Jul, returning Wed, 1 Jul.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Wed, 1 Jul, arriving in Guayaquil.Inbound direct flight with Copa departs from Guayaquil on Wed, 1 Jul, arriving in Panama City Tocumen International.Price includes taxes and charges.From 306 €, select.

Guayaquil.319 € per passenger.Departing Wed, 10 Jun, returning Wed, 17 Jun.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Wed, 10 Jun, arriving in Guayaquil.Inbound indirect flight with Avianca, departs from Guayaquil on Wed, 17 Jun, arriving in Panama City Tocumen International.Price includes taxes and charges.From 319 €, select.

Guayaquil.324 € per passenger.Departing Tue, 30 Jun, returning Tue, 7 Jul.Return flight with Copa and Avianca.Outbound indirect flight with Copa, departs from Panama City Tocumen International on Tue, 30 Jun, arriving in Guayaquil.Inbound indirect flight with Avianca, departs from Guayaquil on Tue, 7 Jul, arriving in Panama City Tocumen International.Price includes taxes and charges.From 324 €, select.

Guayaquil.325 € per passenger.Departing Thu, 18 Jun, returning Sat, 20 Jun.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Thu, 18 Jun, arriving in Guayaquil.Inbound direct flight with Copa departs from Guayaquil on Sat, 20 Jun, arriving in Panama City Tocumen International.Price includes taxes and charges.From 325 €, select.

Guayaquil.327 € per passenger.Departing Wed, 29 Jul, returning Sun, 2 Aug.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Wed, 29 Jul, arriving in Guayaquil.Inbound direct flight with Copa departs from Guayaquil on Sun, 2 Aug, arriving in Panama City Tocumen International.Price includes taxes and charges.From 327 €, select.

Guayaquil.330 € per passenger.Departing Sun, 1 Nov, returning Wed, 4 Nov.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Sun, 1 Nov, arriving in Guayaquil.Inbound direct flight with Copa departs from Guayaquil on Wed, 4 Nov, arriving in Panama City Tocumen International.Price includes taxes and charges.From 330 €, select.

Guayaquil.330 € per passenger.Departing Thu, 15 Oct, returning Sun, 25 Oct.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Thu, 15 Oct, arriving in Guayaquil.Inbound direct flight with Copa departs from Guayaquil on Sun, 25 Oct, arriving in Panama City Tocumen International.Price includes taxes and charges.From 330 €, select.

Guayaquil.333 € per passenger.Departing Thu, 3 Dec, returning Thu, 10 Dec.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Thu, 3 Dec, arriving in Guayaquil.Inbound direct flight with Copa departs from Guayaquil on Thu, 10 Dec, arriving in Panama City Tocumen International.Price includes taxes and charges.From 333 €, select.

Guayaquil.333 € per passenger.Departing Sat, 31 Oct, returning Thu, 5 Nov.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Sat, 31 Oct, arriving in Guayaquil.Inbound direct flight with Copa departs from Guayaquil on Thu, 5 Nov, arriving in Panama City Tocumen International.Price includes taxes and charges.From 333 €, select.

Guayaquil.333 € per passenger.Departing Fri, 28 Aug, returning Fri, 4 Sep.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Fri, 28 Aug, arriving in Guayaquil.Inbound direct flight with Copa departs from Guayaquil on Fri, 4 Sep, arriving in Panama City Tocumen International.Price includes taxes and charges.From 333 €, select.

Guayaquil.333 € per passenger.Departing Fri, 15 Jan, returning Mon, 1 Feb.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Fri, 15 Jan, arriving in Guayaquil.Inbound direct flight with Copa departs from Guayaquil on Mon, 1 Feb, arriving in Panama City Tocumen International.Price includes taxes and charges.From 333 €, select.

Guayaquil.333 € per passenger.Departing Sat, 15 Aug, returning Thu, 20 Aug.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Sat, 15 Aug, arriving in Guayaquil.Inbound direct flight with Copa departs from Guayaquil on Thu, 20 Aug, arriving in Panama City Tocumen International.Price includes taxes and charges.From 333 €, select.

Guayaquil.334 € per passenger.Departing Sun, 27 Dec, returning Sat, 2 Jan.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Sun, 27 Dec, arriving in Guayaquil.Inbound direct flight with Copa departs from Guayaquil on Sat, 2 Jan, arriving in Panama City Tocumen International.Price includes taxes and charges.From 334 €, select.

Guayaquil.334 € per passenger.Departing Fri, 26 Jun, returning Fri, 25 Sep.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Fri, 26 Jun, arriving in Guayaquil.Inbound direct flight with Copa departs from Guayaquil on Fri, 25 Sep, arriving in Panama City Tocumen International.Price includes taxes and charges.From 334 €, select.

Guayaquil.344 € per passenger.Departing Tue, 30 Jun, returning Tue, 7 Jul.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Tue, 30 Jun, arriving in Guayaquil.Inbound direct flight with Copa departs from Guayaquil on Tue, 7 Jul, arriving in Panama City Tocumen International.Price includes taxes and charges.From 344 €, select.

Guayaquil.345 € per passenger.Departing Fri, 11 Sep, returning Fri, 18 Sep.Return flight with Copa and Avianca.Outbound indirect flight with Copa, departs from Panama City Tocumen International on Fri, 11 Sep, arriving in Guayaquil.Inbound indirect flight with Avianca, departs from Guayaquil on Fri, 18 Sep, arriving in Panama City Tocumen International.Price includes taxes and charges.From 345 €, select.

Find the cheapest month to fly from Panama City to Guayaquil

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Panama City to Guayaquil flights are currently cheapest in July.

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Direct flights from Panama City to Guayaquil

Panama City to Guayaquil: Alternative routes

Compare routes from Panama City to Guayaquil below. You may find an airport to fly into that's cheaper, faster, or easier than Guayaquil.

Guayaquil

4km from central Guayaquil

ClosestCheapest

from 306 €

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Panama City to Guayaquil: Flight information

The things to know before you go.

Cheapest flight found	306 €
Cheapest month to fly	July
Average flight time	2 hrs, 16 mins
Most popular airline	Copa
Average flights per week	127

Finding cheap flights from Panama City to Guayaquil: Frequently asked questions

How much are return flights from Panama City to Guayaquil?

The best price we found for a return flight from Panama City to Guayaquil is 306 €. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

How long does it take to fly from Panama City to Guayaquil?

2 hours and 16 minutes is the average flight time from Panama City to Guayaquil.

Which airlines fly direct from Panama City to Guayaquil?

Copa, United and KLM fly direct from Panama City to Guayaquil.

How many flights are there a week from Panama City to Guayaquil?

As of June 2026, there are 127 flights per week flying from Panama City to Guayaquil.

When is the cheapest time to fly from Panama City to Guayaquil?

The cheapest month to fly from Panama City to Guayaquil is usually July.

Which upcoming date is cheapest to fly from Panama City to Guayaquil Airport on?

After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Panama City to Guayaquil Airport on Wednesday, 1 July 2026.

Can I get a direct flight from Panama City to Guayaquil Airport?

Yes – the average flight time is 2 hours and 16 minutes.

How can I find the best flight deal to Guayaquil?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Guayaquil but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to Guayaquil?

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Guayaquil is around 40 days in advance, so don’t leave your flight to the last minute.

Which is the cheapest airline to fly from Panama City to Guayaquil with?

The cheapest airline that flies to Guayaquil is Copa .

Flying from Panama City to Guayaquil Jose Joaquin de Olmedo Intl Airport (GYE): What you need to know

Planning your trip starts with working out where you'll leave from in Panama City. Panama City Tocumen International Airport (PTY) is the city's main airport, so check out your options for booking a flight from Panama City to Guayaquil Jose Joaquin de Olmedo Intl Airport (GYE) out of here.
Take off on a direct Panama City to Guayaquil Jose Joaquin de Olmedo Intl Airport flight and you'll be in the air for around 2 hours 15 minutes.
Guayaquil Jose Joaquin de Olmedo Intl Airport is located in Guayaquil. The city's timezone is UTC-5 — the same as Panama City.
The busiest route is from Panama City Tocumen International Airport (PTY) to Guayaquil Jose Joaquin de Olmedo Intl Airport (GYE), with 40 direct weekly services. If you're not one for hanging around, the earliest flight from PTY to GYE is the 9:01am Copa Airlines service. If a later flight fits your day better, the final departure is at 9:40pm with Copa Airlines.
Get to the airport on time so you don't miss your flight from Panama City to GYE. Be there at least two hours ahead for international flights and an hour early for domestic departures to skip the mad dash to your gate.
Be prepared for longer queues in popular months such as January and other peak periods. Arriving up to four hours ahead of an international flight and two hours for domestic departures is a good idea.

Airports in Panama City

Panama City Tocumen International Airport (PTY)

Panama City Tocumen International Airport (PTY) will have you travelling directly to your destination. Nonstop flights from Panama City to Guayaquil Jose Joaquin de Olmedo Intl Airport (GYE) leave from this terminal.
Copa Airlines is a popular carrier that offers direct flights from Panama City to Guayaquil Jose Joaquin de Olmedo Intl Airport jetting out of PTY.
The preferred airline for passengers flying between PTY and GYE is Copa.
Copa ranks as the leading on-time carrier on this route, with 84.78% of services landing as scheduled.
PTY is about 24 kilometres from central Panama City. If you're ride-sharing, driving or catching a taxi from the centre, it'll take you 35 minutes or so to get there, depending on traffic conditions. If you're planning to take public transport, expect the trip time to be around 50 minutes.
Want an easy start to your holiday? Stay near Panama City Tocumen International Airport. Whether you've booked an early flight from Panama City to Guayaquil Jose Joaquin de Olmedo Intl Airport or prefer not to rush, these hotels are the ideal choice:
Panama City Tocumen International Airport has a strong on-time performance, reducing the likelihood of delays. Departures from PTY land on schedule 88% of the time.

Panama Pacifico International Airport (BLB)

Break up your flight from Panama City to Guayaquil Jose Joaquin de Olmedo Intl Airport with a stop at Bogota El Dorado International Airport (BOG). A major connection between Panama Pacifico International Airport and GYE, it's the perfect opportunity to recharge before the next leg of your journey.
You can reach BLB from central Panama City in about 10 minutes by car (depending on traffic conditions). The journey by public transport takes roughly 20 minutes to travel the 6 kilometres or so.
Start your holiday early with an extra night away from home. Before catching your Panama City to GYE flight, stay in one of these hotels near Panama Pacifico International Airport:
Most flights that leave Panama Pacifico International Airport touch down at their destination as expected. It maintains a high on-time performance rate of 88%.

About Guayaquil Jose Joaquin de Olmedo Intl Airport (GYE)

If you're arriving on a late flight from Panama City to Guayaquil Jose Joaquin de Olmedo Intl Airport, few things beat the convenience of staying close to the terminal. Collect your bags from the carousel and then be showered and snoozing not long after at one of these hotels near GYE:
Lock in the best possible rate by reserving your vehicle around four weeks ahead of your Panama City to Guayaquil Jose Joaquin de Olmedo Intl Airport flight.

Getting from Guayaquil Jose Joaquin de Olmedo Intl Airport (GYE) to central Guayaquil

Central Guayaquil is around 8 kilometres from Guayaquil Jose Joaquin de Olmedo Intl Airport and takes about 20 minutes to reach by car. See what your options are for heading into the city, whether that's with a car hire, taxi or ride-share.
If you're taking public transport, expect a journey of about 35 minutes.

How to find the cheapest flights from Panama City to Guayaquil Jose Joaquin de Olmedo Intl Airport (GYE)

The cheapest price we've found for a one-way ticket from Panama City to Guayaquil Jose Joaquin de Olmedo Intl Airport is 176 €. For a return flight on this route, the best price is 306 €. Depending on the availability when you book, these fares may change.
Book one month before travelling. Research into pricing trends suggests this is the ideal window for finding cheap flights from Panama City to GYE.
Plan your trip for June. That's the best month for scoring an awesome deal on Panama City to Guayaquil Jose Joaquin de Olmedo Intl Airport tickets. If you're open to different travel dates, use the 'Whole month' tool to find the cheapest price across each month.
Finding a cheap plane ticket from Panama City to GYE is a piece of cake with Price Alerts. All you need to do is set up one of these automatic alerts and we'll notify you as soon as there's a price drop.
Tailor your flights using filters. Pick your preferred departure and arrival times, airlines and total journey duration. You can also sort the results by 'Cheapest,' 'Best' or 'Fastest' flights from Panama City to Guayaquil Jose Joaquin de Olmedo Intl Airport.

The best time to fly from Panama City to Guayaquil Jose Joaquin de Olmedo Intl Airport (GYE)

July is the busiest month for flights from Panama City to Guayaquil Jose Joaquin de Olmedo Intl Airport (GYE). Visit Guayaquil in December if you prefer a quieter experience.
The warmest month in Guayaquil is November, with temperatures ranging between 19ºC (66ºF) and 33ºC (91ºF). Book your Panama City to GYE plane ticket then if that's your definition of good weather.
If you want to travel in cooler conditions, search for a cheap ticket from Panama City to Guayaquil Jose Joaquin de Olmedo Intl Airport in August when temperatures are between 19ºC (66ºF) and 32ºC (90ºF).

More about Guayaquil

When it comes to searching for somewhere to rest your head, you'll find the most popular stays in Guayaquil right here. Browse these options as soon as you've booked your flight from Panama City to Guayaquil Jose Joaquin de Olmedo Intl Airport:
You'll find loads of awesome things to do in Guayaquil when you're ready to see the sights. Kick things off at Amazon Rainforest followed by Crystal Palace and Malecon 2000.

Explore more of Ecuador

Quito is just one of the many places in Ecuador waiting to be discovered after you've experienced Guayaquil. Around 274 kilometres away to the northeast, popular attractions include Quito Historic Centre, Catedral Metropolitana de Quito and Camino de los Incas.
Cuenca is another must-experience destination in Ecuador and is around 129 kilometres southeast of Guayaquil. No journey is complete without experiencing Inca Ruins, New Cathedral (Catedral de la Immaculada) and Old Cathedral of Cuenca.