407 € Cheap Flights from Cuzco to Panama City

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Flight deals from Cuzco to Panama City

Looking for a cheap last-minute deal or the best return flight from Cuzco to Panama City? Find the lowest prices on one-way and return tickets right here.

Find the cheapest month to fly from Cuzco to Panama City

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Cuzco to Panama City flights are currently cheapest in November.

Alternative Cuzco to Panama City routes

Looking for the cheapest, fastest or easiest route from Cuzco to Panama City? You could fly into the following airports instead.

Cuzco to Panama City: Flight information

The things to know before you go.
Cheapest flight found407 €
Cheapest month to flyNovember

Finding cheap flights from Cuzco to Panama City: Frequently asked questions

There are 3 airports in Panama City: Panama City Paitilla, Balboa and Panama City Tocumen International.
The best price we found for a return flight from Cuzco to Panama City is 407 €. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Cuzco to Panama City. But we found flights with one or more stops from 407 €.
As of July 2026, there are no flights flying from Cuzco to Panama City.
The cheapest month to fly from Cuzco to Panama City is usually November.
If you're flying from Cuzco Airport, the cheapest airport near Panama City is Panama City Tocumen International – which is 17.9 km away from the centre of Panama City. We've found flights into this airport from 407 €.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Cuzco Airport to Panama City on Friday, 6 November 2026.
No airlines currently offer direct flights between Cuzco Airport and Panama City. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Panama City but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Panama City is around 40 days in advance, so don’t leave your flight to the last minute.

In July, the average temperature is usually around 27°C. May is typically the warmest month in Panama City, when it usually averages around 29°C. You can expect the least rain in February. The coldest month is October, with temperatures averaging 25°C. The rainiest month is June.
Currently, Avianca offers the cheapest flight tickets to Panama City.

Travelling from Cusco Alejandro Velasco Astete Intl Airport (CUZ) to Panama City: what you need to know

  • Cuzco (the location of Cusco Alejandro Velasco Astete Intl Airport) and Panama City follow the same timezone — UTC-5.

  • To avoid missing your CUZ to Panama City flight, leave plenty of time for things like check-in and baggage drop. Arriving two hours ahead of international departures and one hour before domestic flights is the standard rule.

  • Flying during a peak time such as June? Public holidays and other popular periods can mean longer queues at check-in and security. Play things extra safe and arrive up to four hours before an international flight and two hours before a domestic departure.

  • Stopovers offer the opportunity to visit a new place or just take a break during your journey. When booking your plane ticket from CUZ to Panama City, uncheck 'Direct flights only' to compare all potential stops. Bogota El Dorado International Airport (BOG) is a top stop on this route.

  • CUZ is around 3 kilometres from central Cuzco. If you're driving, ride-sharing or catching a taxi from the centre, it'll take 15 minutes or so to get there, depending on the traffic. If you're taking public transport, expect the trip time to be around 20 minutes.

  • Booked an early flight from Cusco Alejandro Velasco Astete Intl Airport to Panama City? Avoid the hassle of rushing to the terminal (and sneak in some extra snooze time) by choosing one of these hotels close to CUZ:

  • When it comes to Cusco Alejandro Velasco Astete Intl Airport's on-time performance, data shows 74% of flights meet their scheduled arrival time.

How to find the cheapest flights from Cusco Alejandro Velasco Astete Intl Airport (CUZ) to Panama City

  • 182 € is the lowest price we've found for a one-way Cusco Alejandro Velasco Astete Intl Airport to Panama City flight. A return plane ticket right now is 407 €. Depending on the availability and when you book, these fares may change.

  • Booking in advance is often the key to securing a cheap flight from CUZ to Panama City. Prices tend to rise as demand increases, so the closer your departure date, the more you'll likely spend on your ticket.

  • If you're flexible with your travel plans, take advantage of the 'Whole month' search tool. It'll give you the lowest price across each month when searching for your Cusco Alejandro Velasco Astete Intl Airport to Panama City ticket.

  • You don't need to check every day to find out if fares have dropped when you create a Price Alert. We'll update you as soon as there's an even bigger deal on cheap flights from CUZ to Panama City.

  • Choose your preferred arrival and departure times, airlines and number of stops with our filters. Then, sort the results for your flight from Cusco Alejandro Velasco Astete Intl Airport to Panama City by 'Fastest,' 'Cheapest' or 'Best.'

Airports in Panama City

Panama City Tocumen International Airport (PTY)

  • The distance from Panama City Tocumen International Airport (PTY) to central Panama City is roughly 24 kilometres. It'll take you around 35 minutes to get to the centre driving.

  • Travelling to the centre on public transport takes around 50 minutes.

  • The last thing you want is a long journey to your hotel if you're landing late on a flight from Cusco Alejandro Velasco Astete Intl Airport to Panama City. Reserve one of these accommodation options near PTY instead:

  • Booking your vehicle from Panama City Tocumen International Airport around three weeks ahead of your flight from CUZ to Panama City can help you get the lowest rate.

Panama Pacifico International Airport (BLB)

  • Panama Pacifico International Airport (BLB) is roughly 6 kilometres from the centre of Panama City. Following your flight from Cusco Alejandro Velasco Astete Intl Airport to Panama City, it'll take you around 10 minutes to get to the heart of the city in a ride-share or taxi.

  • The journey will take about 20 minutes on public transport.

  • After stepping off your CUZ to Panama City flight, unwind at a hotel near BLB. These are some comfortable options that'll help you switch to relaxation mode:

  • Avoid paying extra. Reserving your ride one week ahead of your arrival at BLB can help you lock in a better rate.

Best time to go to Panama City

  • January is the busiest month for flights from Cusco Alejandro Velasco Astete Intl Airport to Panama City. To skip the crowds, head to Panama City in September.

  • The warmest month in Panama City is March, with temperatures ranging between 21ºC (70ºF) and 32ºC (90ºF). Lock in your Cusco Alejandro Velasco Astete Intl Airport to Panama City plane ticket then if that's the weather you find most pleasant.

  • Search for cheap tickets from CUZ to Panama City in January if you like travelling in cooler conditions. Temperatures are at their lowest then, ranging between 22ºC (72ºF) and 31ºC (88ºF) on average.

More about Panama City

  • When it comes to looking for somewhere to lay your head, you'll find the top stays in Panama City right here. Check out these hotels after you've booked your flight from Cusco Alejandro Velasco Astete Intl Airport to Panama City:

  • Metropolitan Cathedral (Catedral Metropolitan) and Casco Viejo are a couple of top attractions to add to your Panama City to-do list. Keep the momentum going by heading to Independence Square.

Explore more of Panama

  • David is just one of the many cities in Panama waiting to be discovered once you've seen Panama City. Around 322 kilometres away to the west, its best attractions include Museo Antropológico y Etnográfico Dr. Roberto De La Guardia, Raptors To The Rescue and Unachi Botanical garden.

  • Another worthwhile stop in Panama, Santiago de Veraguas is around 193 kilometres southwest of Panama City. Make time to visit highlights including Santiago the Apostle Cathedral, Santiago de Veraguas.

Prices shown on this page are estimated lowest prices only. Found in the last 12 days.